Preoperative anxiety-induced glucocorticoid signaling reduces GABAergic markers in spinal cord and promotes postoperative hyperalgesia by affecting neuronal PAS domain protein 4

Preoperative anxiety is common in patients undergoing elective surgery and is closely related to postoperative hyperalgesia. In this study, a single prolonged stress model was used to induce preoperative anxiety-like behavior in rats 24 h before the surgery. We found that single prolonged stress exa...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Wu, Hao, Huang, Yulin, Tian, Xinyu, Zhang, Zuoxia, Zhang, Ying, Mao, Yanting, Wang, Chenchen, Yang, Shuai, Liu, Yue, Zhang, Wei, Ma, Zhengliang
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537253/
https://ncbi.nlm.nih.gov/pubmed/31041873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806919850383
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