Inhibition of N‐myc expression sensitizes human neuroblastoma IMR‐32 cells expressing caspase‐8 to TRAIL

OBJECTIVES: This study aims to explore the roles of N‐myc and caspase‐8 in TRAIL‐resistant IMR‐32 cells which exhibit MYCN oncogene amplification and lack caspase‐8 expression. MATERIALS AND METHODS: We established N‐myc–downregulated IMR‐32 cells using shRNA lentiviral particles targeting N‐myc and...

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Publicado en:Cell Prolif
Autores principales: Lee, Myoung Woo, Kim, Dae Seong, Kim, Hye Ryung, Park, Hyun Jin, Lee, Ji Won, Sung, Ki Woong, Koo, Hong Hoe, Yoo, Keon Hee
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536445/
https://ncbi.nlm.nih.gov/pubmed/30724400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12577
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