Ketogenic and anaplerotic dietary modifications ameliorate seizure activity in Drosophila models of mitochondrial encephalomyopathy and glycolytic enzymopathy

Seizures are a feature not only of the many forms of epilepsy, but also of global metabolic diseases such as mitochondrial encephalomyopathy (ME) and glycolytic enzymopathy (GE). Modern anti-epileptic drugs (AEDs) are successful in many cases, but some patients are refractory to existing AEDs, which...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Fogle, Keri J., Smith, Amber R., Satterfield, Sidney L., Gutierrez, Alejandra C., Hertzler, J. Ian, McCardell, Caleb S., Shon, Joy H., Barile, Zackery J., Novak, Molly O., Palladino, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536302/
https://ncbi.nlm.nih.gov/pubmed/30683556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2019.01.008
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