Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near RASGRP1, which governs the ERK/MAPK kinase cascade and B-/T-cell differentiation and development. However, precise causal RASGRP1 functional varia...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Molineros, Julio E., Singh, Bhupinder, Terao, Chikashi, Okada, Yukinori, Kaplan, Jakub, McDaniel, Barbara, Akizuki, Shuji, Sun, Celi, Webb, Carol F., Looger, Loren L., Nath, Swapan K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536009/
https://ncbi.nlm.nih.gov/pubmed/31164884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01066
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados