Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens

Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers treated by intravenous ceftriaxone (1 g/24 h) or cefotaxi...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Burdet, Charles, Grall, Nathalie, Linard, Morgane, Bridier-Nahmias, Antoine, Benhayoun, Michèle, Bourabha, Khadija, Magnan, Mélanie, Clermont, Olivier, d’Humières, Camille, Tenaillon, Olivier, Denamur, Erick, Massias, Laurent, Tubiana, Sarah, Alavoine, Loubna, Andremont, Antoine, Mentré, France, Duval, Xavier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535507/
https://ncbi.nlm.nih.gov/pubmed/30936104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02244-18
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