Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis

OBJECTIVE(S): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present investigation aims to examine empagliflozin effects on the renal levels of high mobility group box-1 (HMG...

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Detalhes bibliográficos
Publicado no:Iran J Basic Med Sci
Main Authors: Ashrafi Jigheh, Zahra, Ghorbani Haghjo, Amir, Argani, Hassan, Roshangar, Leila, Rashtchizadeh, Nadereh, Sanajou, Davoud, Nazari Soltan Ahmad, Saeed, Rashedi, Jalil, Dastmalchi, Siavoush, Mesgari Abbasi, Mehran
Formato: Artigo
Idioma:Inglês
Publicado em: Mashhad University of Medical Sciences 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535193/
https://ncbi.nlm.nih.gov/pubmed/31168342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2019.31788.7651
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