Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

An expanded (G4C2)30+ repeat within C9orf72 is the most prominent mutation in familial FTD and ALS. Through an unbiased, large-scale screen in (G4C2)49-expressing Drosophila we identify the CDC73/PAF1 complex (PAF1C), a transcriptional regulator of RNAPII, as a suppressor of G4C2-associated toxicity...

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Publicat a:Nat Neurosci
Autors principals: Goodman, Lindsey D., Prudencio, Mercedes, Kramer, Nicholas J., Martinez-Ramirez, Luis F., Srinivasan, Ananth R., Lan, Matthews, Parisi, Michael J., Zhu, Yongqing, Chew, Jeannie, Cook, Casey N., Berson, Amit, Gitler, Aaron D., Petrucelli, Leonard, Bonini, Nancy M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535128/
https://ncbi.nlm.nih.gov/pubmed/31110321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0396-1
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