Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry

The human genetic basis of tuberculosis (TB) has long remained elusive. We recently reported a high level of enrichment in homozygosity for the common TYK2 P1104A variant in a heterogeneous cohort of patients with TB from non-European countries in which TB is endemic. This variant is homozygous in ∼...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kerner, Gaspard, Ramirez-Alejo, Noe, Seeleuthner, Yoann, Yang, Rui, Ogishi, Masato, Cobat, Aurélie, Patin, Etienne, Quintana-Murci, Lluis, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent, Abel, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534977/
https://ncbi.nlm.nih.gov/pubmed/31068474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903561116
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