Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry

The human genetic basis of tuberculosis (TB) has long remained elusive. We recently reported a high level of enrichment in homozygosity for the common TYK2 P1104A variant in a heterogeneous cohort of patients with TB from non-European countries in which TB is endemic. This variant is homozygous in ∼...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Kerner, Gaspard, Ramirez-Alejo, Noe, Seeleuthner, Yoann, Yang, Rui, Ogishi, Masato, Cobat, Aurélie, Patin, Etienne, Quintana-Murci, Lluis, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent, Abel, Laurent
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534977/
https://ncbi.nlm.nih.gov/pubmed/31068474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903561116
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