Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data. quanTIseq analysis of 8000 tumor samples revealed that cyt...

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Publicat a:Genome Med
Autors principals: Finotello, Francesca, Mayer, Clemens, Plattner, Christina, Laschober, Gerhard, Rieder, Dietmar, Hackl, Hubert, Krogsdam, Anne, Loncova, Zuzana, Posch, Wilfried, Wilflingseder, Doris, Sopper, Sieghart, Ijsselsteijn, Marieke, Brouwer, Thomas P., Johnson, Douglas, Xu, Yaomin, Wang, Yu, Sanders, Melinda E., Estrada, Monica V., Ericsson-Gonzalez, Paula, Charoentong, Pornpimol, Balko, Justin, de Miranda, Noel Filipe da Cunha Carvahlo, Trajanoski, Zlatko
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534875/
https://ncbi.nlm.nih.gov/pubmed/31126321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0638-6
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