Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Encoding and retrieval of contextual memories is initially mediated by sparsely activated neurons, so-called engram cells, in the hippocampus. Subsequent memory persistence is thought to depend on network-wide changes involving progressive contribution of cortical regions, a process referred to as s...

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Publicado en:Nat Commun
Autores principales: Matos, Mariana R., Visser, Esther, Kramvis, Ioannis, van der Loo, Rolinka J., Gebuis, Titia, Zalm, Robbert, Rao-Ruiz, Priyanka, Mansvelder, Huibert D., Smit, August B., van den Oever, Michel C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534583/
https://ncbi.nlm.nih.gov/pubmed/31127098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10266-1
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