Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

Candida albicans is a fungal pathobiont, able to cause epithelial cell damage and immune activation. These functions have been attributed to its secreted toxin, candidalysin, though the molecular mechanisms are poorly understood. Here, we identify epidermal growth factor receptor (EGFR) as a critica...

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Udgivet i:Nat Commun
Main Authors: Ho, Jemima, Yang, Xuexin, Nikou, Spyridoula-Angeliki, Kichik, Nessim, Donkin, Andrew, Ponde, Nicole O., Richardson, Jonathan P., Gratacap, Remi L., Archambault, Linda S., Zwirner, Christian P., Murciano, Celia, Henley-Smith, Rhonda, Thavaraj, Selvam, Tynan, Christopher J., Gaffen, Sarah L., Hube, Bernhard, Wheeler, Robert T., Moyes, David L., Naglik, Julian R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534540/
https://ncbi.nlm.nih.gov/pubmed/31127085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09915-2
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