Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals

The six C. elegans vulval precursor cells (VPCs) are induced to form the 3°-3°-2°-1°-2°-3° pattern of cell fates with high fidelity. In response to EGF signal, the LET-60/Ras-LIN-45/Raf-MEK-2/MEK-MPK-1/ERK canonical MAP kinase cascade is necessary to induce 1° fate and synthesis of DSL ligands for t...

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Bibliografiska uppgifter
I publikationen:PLoS Genet
Huvudupphovsmän: Shin, Hanna, Braendle, Christian, Monahan, Kimberly B., Kaplan, Rebecca E. W., Zand, Tanya P., Mote, Francisca Sefakor, Peters, Eldon C., Reiner, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534338/
https://ncbi.nlm.nih.gov/pubmed/31086367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008056
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