Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures

BACKGROUND: L-Glutamate (L-Glu), the major excitatory neurotransmitter in the mammalian Central Nervous System (CNS), is essential to cognitive functions. However, when L-Glu is accumulated in large concentrations at the synaptic cleft, it can induce excitotoxicity that results in secondary damage i...

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Bibliografiske detaljer
Udgivet i:J Venom Anim Toxins Incl Trop Dis
Main Authors: Primini, Eduardo Octaviano, Liberato, José Luiz, Fontana, Andreia Cristina Karklin, dos Santos, Wagner Ferreira
Format: Artigo
Sprog:Inglês
Udgivet: Centro de Estudos de Venenos e Animais Peçonhentos 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533932/
https://ncbi.nlm.nih.gov/pubmed/31131008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-9199-JVATITD-1488-18
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