l‐α‐Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK‐dependent pathway

The phospholipid l‐α‐lysophosphatidylinositol (LPI), an endogenous ligand for GPR55, is elevated in patients with acute coronary syndrome, and a GPR55 antagonist cannabidiol (CBD) reduces experimental ischemia/reperfusion (I/R) injury. While LPI activates multiple signaling pathways, little is known...

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Bibliographic Details
Published in:Pharmacol Res Perspect
Main Authors: Robertson‐Gray, Olivia J., Walsh, Sarah K., Ryberg, Erik, Jönsson‐Rylander, Ann‐Cathrine, Lipina, Christopher, Wainwright, Cherry L.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533556/
https://ncbi.nlm.nih.gov/pubmed/31149342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.487
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