IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

BACKGROUND: Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute spinal cord injury (SCI). Here, we investigated whether BMMSCs overexpressing insulin-like growth factor 1 (IGF-1), a cytokine invol...

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Pubblicato in:Stem Cell Res Ther
Autori principali: Allahdadi, Kyan James, de Santana, Thaís Alves, Santos, Girlaine Café, Azevedo, Carine Machado, Mota, Roberta Alves, Nonaka, Carolina Kymie, Silva, Daniela Nascimento, Valim, Clarissa Xavier Resende, Figueira, Cláudio Pereira, dos Santos, Washington Luis Conrado, do Espirito Santo, Renan Fernandes, Evangelista, Afrânio Ferreira, Villarreal, Cristiane Flora, dos Santos, Ricardo Ribeiro, de Souza, Bruno Solano Freitas, Soares, Milena Botelho Pereira
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530133/
https://ncbi.nlm.nih.gov/pubmed/31113444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1223-z
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