Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models

BACKGROUND: Breast cancer is the second leading cause of cancer deaths in the USA. Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer with high rates of metastasis, tumor recurrence, and resistance to therapeutics. Obesity, defined by a high body mass index (BMI...

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Publicado en:Breast Cancer Res
Autores principales: Sabol, Rachel A., Bowles, Annie C., Côté, Alex, Wise, Rachel, O’Donnell, Benjamen, Matossian, Margarite D., Hossain, Fokhrul M., Burks, Hope E., Del Valle, Luis, Miele, Lucio, Collins-Burow, Bridgette M., Burow, Matthew E., Bunnell, Bruce A.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530039/
https://ncbi.nlm.nih.gov/pubmed/31118047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1153-9
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