Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived proteins; how ubiquitylation modifies the long-lived proteome and its regulatory effect on adult l...

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Vydáno v:Nat Commun
Hlavní autoři: Yang, Lu, Ma, Zaijun, Wang, Han, Niu, Kongyan, Cao, Ye, Sun, Le, Geng, Yang, Yang, Bo, Gao, Feng, Chen, Zuolong, Wu, Zhen, Li, Qingqing, Shen, Yong, Zhang, Xumin, Jiang, Hong, Chen, Yelin, Liu, Rui, Liu, Nan, Zhang, Yaoyang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529468/
https://ncbi.nlm.nih.gov/pubmed/31113955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10136-w
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