PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Cachexia is frequently accompanied by severe metabolic derangements, although the mechanisms responsible for this debilitating condition remain unclear. Pyruvate dehydrogenase kinase (PDK)4, a critical regulator of cellular energetic metabolism, was found elevated in experimental models of cancer, s...

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Publicat a:FASEB J
Autors principals: Pin, Fabrizio, Novinger, Leah J., Huot, Joshua R., Harris, Robert A., Couch, Marion E., O’Connell, Thomas M., Bonetto, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529344/
https://ncbi.nlm.nih.gov/pubmed/30894018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802799R
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