Hyper activation of β‐catenin signalling induced by IKKε inhibition thwarts colorectal cancer cell proliferation

OBJECTIVE: Aberrant activation of Wnt/β‐catenin signalling contributes significantly to the development of human colorectal cancers and β‐catenin is the key signalling molecule transducing canonical Wnt/β‐catenin signalling. Therefore, β‐catenin is a promising therapeutic target for cancer treatment...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Chen, Jie, Zhao, Jun, Chen, Xuan, Ding, Chengming, Lee, Katie, Jia, Zeming, Zhang, Yaoting, Zhou, Yuzheng, Wei, Chaoying, He, Jiantai, Xia, Zanxian, Peng, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529108/
https://ncbi.nlm.nih.gov/pubmed/28523736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12350
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