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Cathepsin B regulates non‐canonical NLRP3 inflammasome pathway by modulating activation of caspase‐11 in Kupffer cells
OBJECTIVES: The non‐canonical inflammasome pathway was described which engages caspase‐11 to mediate pyroptosis and the subsequent release of IL‐1α, IL‐1β and IL‐18 in TLR4‐independent way. Cathepsin B is capable of activating caspase‐11 under cell‐free conditions which may regulate non‐canonical NL...
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| Gepubliceerd in: | Cell Prolif |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6528937/ https://ncbi.nlm.nih.gov/pubmed/30084208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12487 |
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