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Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection

DNA in the human Herpes simplex virus type 1 (HSV-1) capsid is packaged to a tight density. This leads to tens of atmospheres of internal pressure responsible for the delivery of the herpes genome into the cell nucleus. In this study we show that, despite its liquid crystalline state inside the caps...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Sae-Ueng, Udom, Li, Dong, Zuo, Xiaobing, Huffman, Jamie B, Homa, Fred L, Rau, Donald, Evilevitch, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528806/
https://ncbi.nlm.nih.gov/pubmed/25195012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1628
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