Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture

BACKGROUND: Repeated culture reduces within-sample Mycobacterium tuberculosis genetic diversity due to selection of clones suited to growth in culture and/or random loss of lineages, but it is not known to what extent omitting the culture step altogether alters genetic diversity. We compared M. tube...

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I publikationen:BMC Genomics
Huvudupphovsmän: Nimmo, Camus, Shaw, Liam P., Doyle, Rona, Williams, Rachel, Brien, Kayleen, Burgess, Carrie, Breuer, Judith, Balloux, Francois, Pym, Alexander S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528373/
https://ncbi.nlm.nih.gov/pubmed/31109296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-5782-2
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