The STELLAR trial protocol: a prospective multicentre trial for Richter’s syndrome consisting of a randomised trial investigation CHOP-R with or without acalabrutinib for newly diagnosed RS and a single-arm platform study for evaluation of novel agents in relapsed disease

BACKGROUND: Transformation of chronic lymphocytic leukaemia (CLL) to diffuse large B-cell lymphoma (DLCBL) type Richter’s syndrome (RS) carries a dismal prognosis. Standard-of-care chemoimmunotherapy for de novo RS is inadequate with median survival of less than one year. Patients are frequently eld...

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Publicado en:BMC Cancer
Autores principales: Appleby, Niamh, Eyre, Toby A., Cabes, Maite, Jackson, Aimee, Boucher, Rebecca, Yates, Francesca, Fox, Sonia, Rawstron, Andrew, Hillmen, Peter, Schuh, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528290/
https://ncbi.nlm.nih.gov/pubmed/31109313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5717-y
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