R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling

BACKGROUND: Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) and functional blood cells from hPSCs remains largely elusive. METHOD: In this...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Wang, Yv, Gao, Jie, Wang, Hongtao, Wang, Mengge, Wen, Yuqi, Guo, Jiaojiao, Su, Pei, Shi, Lihong, Zhou, Wen, Zhou, Jiaxi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528258/
https://ncbi.nlm.nih.gov/pubmed/31109354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1242-9
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