R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling

BACKGROUND: Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) and functional blood cells from hPSCs remains largely elusive. METHOD: In this...

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Dettagli Bibliografici
Pubblicato in:Stem Cell Res Ther
Autori principali: Wang, Yv, Gao, Jie, Wang, Hongtao, Wang, Mengge, Wen, Yuqi, Guo, Jiaojiao, Su, Pei, Shi, Lihong, Zhou, Wen, Zhou, Jiaxi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528258/
https://ncbi.nlm.nih.gov/pubmed/31109354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1242-9
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