BI1071, a novel Nur77 modulator, induces apoptosis of cancer cells by activating the Nur77-Bcl-2 apoptotic pathway

Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 to convert Bcl-2 from an anti-apoptotic to a pro-apoptotic molecule. Nur77 posttranslational modification such as phosphorylation...

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Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Chen, Xiaohui, Cao, Xihua, Tu, Xuhuang, Alitongbieke, Gulimiran, Xia, Zebin, Li, Xiaotong, Chen, Ziwen, Yin, Meimei, Xu, Dan, Guo, Shangjie, Li, Zongxi, Chen, Liqun, Zhang, Xindao, Xu, Dingyu, Gao, Meichun, Liu, Jie, Zeng, Zhiping, Zhou, Hu, Su, Ying, Zhang, Xiao-kun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527444/
https://ncbi.nlm.nih.gov/pubmed/30926635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0918
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