Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells

The subcellular mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in gastric cancer and normal mucosal cells is elusive because of the diverse cyclooxygenase-independent effects of these drugs. Using human gastric carcinoma cells (AGSs) and a rat gastric injury model,...

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Vydáno v:J Biol Chem
Hlavní autoři: Mazumder, Somnath, De, Rudranil, Debsharma, Subhashis, Bindu, Samik, Maity, Pallab, Sarkar, Souvik, Saha, Shubhra Jyoti, Siddiqui, Asim Azhar, Banerjee, Chinmoy, Nag, Shiladitya, Saha, Debanjan, Pramanik, Saikat, Mitra, Kalyan, Bandyopadhyay, Uday
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527165/
https://ncbi.nlm.nih.gov/pubmed/30940726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004415
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