Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange

Resistance to inhibitors of cholinesterase-8A (Ric-8A) and Ric-8B are essential biosynthetic chaperones for hetero-trimeric G protein α subunits. We provide evidence for the direct regulation of Ric-8A cellular activity by dual phosphorylation. Using proteomics, Western blotting, and mutational anal...

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Publicado no:Sci Signal
Main Authors: Papasergi-Scott, Makaía M., Stoveken, Hannah M., MacConnachie, Lauren, Chan, Pui-Yee, Gabay, Meital, Wong, Dorothy, Freeman, Robert S., Beg, Asim A., Tall, Gregory G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526509/
https://ncbi.nlm.nih.gov/pubmed/29844055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aap8113
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