A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor

Subtilase cytotoxin (SubAB) is a virulence factor produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains. The toxin recognizes sialoglycans for entry and cleaves an endoplasmic reticulum chaperon, binding immunoglobulin protein, to cause cell death. However, no...

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Vydáno v:iScience
Hlavní autoři: Yamaji, Toshiyuki, Hanamatsu, Hisatoshi, Sekizuka, Tsuyoshi, Kuroda, Makoto, Iwasaki, Norimasa, Ohnishi, Makoto, Furukawa, Jun-ichi, Yahiro, Kinnosuke, Hanada, Kentaro
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526310/
https://ncbi.nlm.nih.gov/pubmed/31108395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.05.005
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