HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain barrier (BBB) permeability is a critical neurovascular complication of T2DM that adversely affects the central nervous system homeo...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Zhao, Qiuchen, Zhang, Fang, Yu, Zhanyang, Guo, Shuzhen, Liu, Ning, Jiang, Yinghua, Lo, Eng H., Xu, Yun, Wang, Xiaoying
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525453/
https://ncbi.nlm.nih.gov/pubmed/31101061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1495-3
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