Multi-metal restriction by calprotectin impacts de novo flavin biosynthesis in Acinetobacter baumannii

Calprotectin (CP) inhibits bacterial viability through extracellular chelation of transition metals. However, how CP impacts general metabolism remains largely unexplored. We show here that CP restricts bioavailable Zn and Fe to the pathogen Acinetobacter baumannii, inducing an extensive multi-metal...

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Udgivet i:Cell Chem Biol
Main Authors: Wang, Jiefei, Lonergan, Zachery R., Gonzalez-Gutierrez, Giovanni, Nairn, Brittany L., Maxwell, Christina N., Zhang, Yixiang, Andreini, Claudia, Karty, Jonathan A., Chazin, Walter J., Trinidad, Jonathan C., Skaar, Eric P., Giedroc, David P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525019/
https://ncbi.nlm.nih.gov/pubmed/30905682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.011
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