HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression

Understanding oxidative stress and HTRA1 locus in abnormal angiogenesis resulting in wet AMD pathology is an important step in developing a novel therapeutic approach. Using subretinal injection of oxLDL into C57BL/6 mice, we observed a lesion resembling the features of choroidal neovascularization...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lu, Zhigang, Lin, Victor, May, Adam, Che, Briana, Xiao, Xu, Shaw, Daniel H., Su, Fei, Wang, Zhihao, Du, Hongjun, Shaw, Peter X.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524793/
https://ncbi.nlm.nih.gov/pubmed/31100080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216808
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