Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study

Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhibiting...

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Vydáno v:Cells
Hlavní autoři: Fiorelli, Susanna, Porro, Benedetta, Cosentino, Nicola, Di Minno, Alessandro, Manega, Chiara Maria, Fabbiocchi, Franco, Niccoli, Giampaolo, Fracassi, Francesco, Barbieri, Simone, Marenzi, Giancarlo, Crea, Filippo, Cavalca, Viviana, Tremoli, Elena, Eligini, Sonia
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523494/
https://ncbi.nlm.nih.gov/pubmed/30995787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8040356
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