Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity

BACKGROUND & AIMS: The lysosome is an acidic organelle that is important for maintaining cellular and metabolic homeostasis in hepatocytes. Lysosomal dysfunction and chronic inflammation coexist, and both contribute to obesity-associated hepatic insulin resistance. However, in the context of obe...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Qian, Qingwen, Zhang, Zeyuan, Li, Mark, Savage, Kalie, Cheng, Dechun, Rauckhorst, Adam J., Ankrum, James A., Taylor, Eric B., Ding, Wen-xing, Xiao, Yi, Cao, Huo-jun, Yang, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522853/
https://ncbi.nlm.nih.gov/pubmed/30926581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.03.005
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