Antithrombin III Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Excessive Autophagy in a Phosphoinositide 3-Kinase/Akt-Dependent Manner

Autophagy is fundamental to myocardial ischemia/reperfusion (I/R) injury. Antithrombin III (AT) has been shown to protect cardiomyocytes against I/R injury; however, it is unknown whether it modulates autophagy. The objective of this study was to investigate whether AT regulates autophagy during I/R...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Huang, Kai-yu, Wang, Jiao-ni, Zhou, Ying-ying, Wu, Shao-ze, Tao, Lu-yuan, Peng, Yang-pei, Que, Jia-qun, Xue, Yang-jing, Ji, Kang-ting
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522837/
https://ncbi.nlm.nih.gov/pubmed/31133861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00516
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