Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

HIV-infected infants develop broadly neutralizing plasma responses with more rapid kinetics than adults, suggesting the ontogeny of infant responses could better inform a path to achievable vaccine targets. Here we reconstruct the developmental lineage of BF520.1, an infant-derived HIV-specific broa...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Simonich, Cassandra A., Doepker, Laura, Ralph, Duncan, Williams, James A., Dhar, Amrit, Yaffe, Zak, Gentles, Lauren, Small, Christopher T., Oliver, Brian, Vigdorovich, Vladimir, Mangala Prasad, Vidya, Nduati, Ruth, Sather, D. Noah, Lee, Kelly K., Matsen IV, Frederick A., Overbaugh, Julie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522554/
https://ncbi.nlm.nih.gov/pubmed/31097697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09481-7
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