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miR-23b-3p suppressing PGC1α promotes proliferation through reprogramming metabolism in osteosarcoma

Metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis is a hallmark of osteosarcoma (OS). However, the mechanisms of the metabolic switch have not been completely elucidated. Here we reported that the miR-23b-3p was significantly upregulated in OS cells. Functional studies suggested...

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Podrobná bibliografie
Vydáno v:Cell Death Dis
Hlavní autoři: Zhu, Ran, Li, Xinpan, Ma, Yanhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522531/
https://ncbi.nlm.nih.gov/pubmed/31097683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1614-1
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