Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

T-cells play a crucial role in progression of autoimmunity, including vitiligo, yet the initial steps triggering their activation and tissue damage remain unknown. Here we demonstrate increased presence of type-1 innate lymphoid cells (NK and ILC1)-producing interferon gamma (IFNγ) in the blood and...

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Publicat a:Nat Commun
Autors principals: Tulic, Meri K., Cavazza, Elisa, Cheli, Yann, Jacquel, Arnaud, Luci, Carmelo, Cardot-Leccia, Nathalie, Hadhiri-Bzioueche, Hanene, Abbe, Patricia, Gesson, Maéva, Sormani, Laura, Regazzetti, Claire, Beranger, Guillaume E., Lereverend, Cedric, Pons, Caroline, Khemis, Abdallah, Ballotti, Robert, Bertolotto, Corine, Rocchi, Stéphane, Passeron, Thierry
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522502/
https://ncbi.nlm.nih.gov/pubmed/31097717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09963-8
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