Reversal of Vocal Fold Mucosal Fibrosis Using siRNA against the Collagen-Specific Chaperone Serpinh1

Vocal fold (VF) mucosal fibrosis results in substantial voice impairment and is recalcitrant to current treatments. To reverse this chronic disorder, anti-fibrotic therapies should target the molecular pathology of aberrant collagen accumulation in the extracellular matrix. We investigated the thera...

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Gepubliceerd in:Mol Ther Nucleic Acids
Hoofdauteurs: Kishimoto, Yo, Yamashita, Masaru, Wei, Alice, Toya, Yutaka, Ye, Shuyun, Kendziorski, Christina, Welham, Nathan V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520554/
https://ncbi.nlm.nih.gov/pubmed/31100613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.04.014
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