Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

BACKGROUND: Sepsis still represents a major health issue, with persistent high morbidity and mortality rates. Cardiovascular dysfunction occurs frequently during sepsis. Adrenomedullin has been identified as a key mediator in vascular tone regulation. A non-neutralizing anti-adrenomedullin antibody,...

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Bibliographische Detailangaben
Veröffentlicht in:Intensive Care Med Exp
Hauptverfasser: Blet, Alice, Deniau, Benjamin, Geven, Christopher, Sadoune, Malha, Caillard, Anaïs, Kounde, Paul-Robert, Polidano, Evelyne, Pickkers, Peter, Samuel, Jane-Lise, Mebazaa, Alexandre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520420/
https://ncbi.nlm.nih.gov/pubmed/31093784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-019-0255-0
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