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Use of a Stereochemical Strategy to Probe the Mechanism of Phenol-Soluble Modulin α3 Toxicity
Phenol-soluble modulin α3 (PSMα3) is a cytotoxic peptide secreted by virulent strains of Staphylococcus aureus. We used a stereochemical strategy to examine the mechanism of PSMα3-mediated toxicity. One hypothesis is that PSMα3 toxicity requires fibril formation; an alternative is that toxicity is c...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6520131/ https://ncbi.nlm.nih.gov/pubmed/31045358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b00349 |
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