Discovery of widespread Type I and Type V CRISPR-Cas inhibitors

Bacterial CRISPR-Cas systems protect their host from bacteriophages and other mobile genetic elements. Mobile elements, in turn, encode various anti-CRISPR (Acr) proteins to inhibit the immune function of CRISPR-Cas. To date, Acr proteins have been discovered for type I (subtypes I-D, I-E, and I-F)...

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Udgivet i:Science
Main Authors: Marino, Nicole D., Zhang, Jenny Y., Borges, Adair L., Sousa, Alexander A., Leon, Lina M., Rauch, Benjamin J., Walton, Russell T., Berry, Joel D., Joung, J. Keith, Kleinstiver, Benjamin P., Bondy-Denomy, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520112/
https://ncbi.nlm.nih.gov/pubmed/30190308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau5174
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