Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix

Diseases that lead to blood-brain barrier (BBB) disruption will pathologically expose normally inaccessible brain extracellular matrix (ECM) to circulating blood components. Therefore, we hypothesized that brain ECM-targeting moieties could specifically target the disrupted BBB and potentially deliv...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Umlauf, Benjamin J., Clark, Paul A., Lajoie, Jason M., Georgieva, Julia V., Bremner, Samantha, Herrin, Brantley R., Kuo, John S., Shusta, Eric V.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520025/
https://ncbi.nlm.nih.gov/pubmed/31106264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau4245
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