Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice

Haploinsufficiency of the protein kinase Tbk1 has shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the pathogenic mechanisms are unclear. Here we show that conditional neuronal deletion of Tbk1 in leads to cognitive and locomotor deficits in mice. T...

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Publicado en:Aging (Albany NY)
Autores principales: Duan, Weisong, Guo, Moran, Yi, Le, Zhang, Jie, Bi, Yue, Liu, Yakun, Li, Yuanyuan, Li, Zhongyao, Ma, Yanqin, Zhang, Guisen, Liu, Yaling, Song, Xueqing, Li, Chunyan
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519994/
https://ncbi.nlm.nih.gov/pubmed/31039129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101936
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