The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial

Rationale: There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and antimuscarinic effects improve genioglossus muscle activity and upper airway patency during sleep. Objectives: We aimed to determin...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Taranto-Montemurro, Luigi, Messineo, Ludovico, Sands, Scott A., Azarbarzin, Ali, Marques, Melania, Edwards, Bradley A., Eckert, Danny J., White, David P., Wellman, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519859/
https://ncbi.nlm.nih.gov/pubmed/30395486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201808-1493OC
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