Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability

Proteolytic cleavage of synaptosomal-associated protein 25 by the light chain of botulinum neurotoxin type A (LCA) results in a blockade of neurotransmitter release that persists for several months in motor neurons. The L428A/L429A mutation in LCA is known to significantly shorten both the proteolyt...

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Detaylı Bibliyografya
Yayımlandı:J Cell Sci
Asıl Yazarlar: Vagin, Olga, Tokhtaeva, Elmira, Garay, Patton E., Souda, Puneet, Bassilian, Sara, Whitelegge, Julian P., Lewis, Ramilla, Sachs, George, Wheeler, Larry, Aoki, Roger, Fernandez-Salas, Ester
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518159/
https://ncbi.nlm.nih.gov/pubmed/24928902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.146324
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