IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing and remodeling, features that are dysfunctional in patients with cystic fibrosis (CF). The mechanisms by which ILCs contribute to CF-...

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Udgivet i:Nat Commun
Main Authors: Golebski, Korneliusz, Ros, Xavier R., Nagasawa, Maho, van Tol, Sophie, Heesters, Balthasar A., Aglmous, Hajar, Kradolfer, Chantal M. A., Shikhagaie, Medya M., Seys, Sven, Hellings, P. W., van Drunen, Cornelis M., Fokkens, Wytske J., Spits, Hergen, Bal, Suzanne M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517442/
https://ncbi.nlm.nih.gov/pubmed/31089134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09883-7
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