IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that mast cells are aberrantly activated in human and...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wang, Qian, Lepus, Christin M, Raghu, Harini, Reber, Laurent L, Tsai, Mindy M, Wong, Heidi H, von Kaeppler, Ericka, Lingampalli, Nithya, Bloom, Michelle S, Hu, Nick, Elliott, Eileen E, Oliviero, Francesca, Punzi, Leonardo, Giori, Nicholas J, Goodman, Stuart B, Chu, Constance R, Sokolove, Jeremy, Fukuoka, Yoshihiro, Schwartz, Lawrence B, Galli, Stephen J, Robinson, William H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516833/
https://ncbi.nlm.nih.gov/pubmed/31084709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39905
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