Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for congenital heart defects prevention

BACKGROUNDS: Reducing toxicants transplacental rates could contribute to the prevention of congenital heart defects (CHDs). Placental P-glycoprotein (P-gp) plays a vital role in fetal toxicants exposure and subsequently affects the risk of toxicants-induced birth defects. However, data on the role o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tang, Changqing, Luo, Chunyan, Hua, Yimin, Zhou, Kaiyu, Duan, Hongyu, Ma, Fan, Zhang, Yi, Li, Yifei, Qiu, Dajian, Wang, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516658/
https://ncbi.nlm.nih.gov/pubmed/31086358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214873
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