Propofol improved hypoxia‐impaired integrity of blood‐brain barrier via modulating the expression and phosphorylation of zonula occludens‐1

AIMS: Hypoxia may damage blood‐brain barrier (BBB). The neuroprotective effect of propofol has been reported. We aimed to identify whether and how propofol improved hypoxia‐induced impairment of BBB integrity. METHODS: Mouse brain microvascular endothelial cells (MBMECs) and astrocytes were cocultur...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Chen, Wei, Ju, Xing‐Zhu, Lu, Yan, Ding, Xiao‐Wei, Miao, Chang‐Hong, Chen, Jia‐Wei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515893/
https://ncbi.nlm.nih.gov/pubmed/30680941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13101
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