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Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT(1A) Ligands: Binding and Docking Studies

Trazodone, a well-known antidepressant drug widely used throughout the world, works as a 5-hydroxytryptamine (5-HT(2)) and α(1)-adrenergic receptor antagonist and a serotonin reuptake inhibitor. Our research aimed to develop a new method for the synthesis of trazodone and its derivatives. In the kno...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Jaśkowska, Jolanta, Zaręba, Przemysław, Śliwa, Paweł, Pindelska, Edyta, Satała, Grzegorz, Majka, Zbigniew
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515286/
https://ncbi.nlm.nih.gov/pubmed/31018618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081609
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